As the antimalarial drugs hydroxychloroquine and chloroquine have drawn attention as potential therapies for COVID-19 and are being widely used off-label, it’s now more important than ever to have a thorough assessment of the safety of these medications. A recent analysis published in the British Journal of Clinical Pharmacology provides new insights.
In the analysis of real-world data from the Food and Drug Administration Adverse Events Reporting System, a global database of post-marketing safety reports, hydroxychloroquine and chloroquine were associated with higher rates of various cardiovascular problems, including life-threatening heart rhythm events, heart failure, and damage to the heart muscle itself (termed cardiomyopathy).
“Moreover, we show how these adverse events carry high risks for severe outcomes including death, even with standard doses of the drugs,” said senior author Elad Maor, MD, PhD, of Sheba Medical Center and Tel-Aviv University, in Israel. “The take-home message of our work is that physicians around the world should be careful when prescribing these drugs for off-label indications, especially for patients with cardiac disorders.”
Peer Reviewed Observational Study Human
Additional Information
Link to Study: https://onlinelibrary.wiley.com/doi/10.1111/bcp.14546
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Published on behalf of the British Pharmacological Society, the British Journal of Clinical Pharmacology features papers and reports on all aspects of drug action in humans: review articles, mini review articles, original papers, commentaries, editorials and letters. The Journal enjoys a wide readership, bridging the gap between the medical profession, clinical research and the pharmaceutical industry. It also publishes research on new methods, new drugs and new approaches to treatment. The Journal is recognised as one of the leading publications in its field. It is online only, publishes open access research through its OnlineOpen programme and is published monthly.
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