Cell-free DNA (cfDNA) testing, which involves analyzing fetal DNA in a maternal blood sample, is a non-invasiveness and highly accurate test for Down syndrome in singleton pregnancies, but its effectiveness in twin pregnancies has been unclear. A new analysis published in Ultrasound in Obstetrics & Gynecology reveals that cfDNA testing for Down syndrome in twins is just as effective as in singletons, with a detection rate of 98% and only a 0.05% rate of misdiagnosis.
Cell-free DNA (cfDNA) testing, which involves analyzing fetal DNA in a maternal blood sample, is a non-invasiveness and highly accurate test for Down syndrome in singleton pregnancies, but its effectiveness in twin pregnancies has been unclear. A new analysis published in Ultrasound in Obstetrics & Gynecology reveals that cfDNA testing for Down syndrome in twins is just as effective as in singletons, with a detection rate of 98% and only a 0.05% rate of misdiagnosis.
The analysis combined information from a dataset of 997 twin pregnancies in addition to results from seven previously published studies.
In many countries, including the United States, cfDNA testing is not recommended for use in twin pregnancies. These latest findings provide compelling evidence that mothers carrying twins should not be denied this safe and effective test.
Additional Information
Link to Study: https://onlinelibrary.wiley.com/doi/10.1002/uog.20284
About Journal
The Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG), Ultrasound in Obstetrics & Gynecology (UOG) is an international, peer-reviewed journal. Published monthly, the journal includes original papers, case reports, reviews, Editorial and Opinion articles, and a letters column. UOG is covered by all the primary indexes including Index Medicus and Current Contents, and is read by Obstetricians, Gynecologists, Radiologists, Pediatricians, Sonographers, Midwives and Radiographers.
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