Researchers who analyzed gene expression in synovial tissue samples from rheumatoid arthritis patients’ joints identified different patterns that may be clinically meaningful.
Researchers who analyzed gene expression in synovial tissue samples from rheumatoid arthritis patients’ joints identified different patterns that may be clinically meaningful. The findings, which are published in Arthritis & Rheumatology, indicate that the mechanisms of pain differ in patients with different synovial subtypes of rheumatoid arthritis, and they may help guide clinicians as they develop optimal treatment strategies for patients.
“We were surprised to find that some patients had high pain, tenderness, and even swollen joint counts while exhibiting minimal inflammation in their tissue or blood. This suggests that some patients can have high disease activity scores with little inflammation,” said lead author Dr. Dana Orange, of The Rockefeller University. “It stands to reason that patients with minimal tissue inflammation may not respond to our usual immune-targeting drugs.”
Additional Information
Link to Study: http://doi.wiley.com/10.1002/art.40428
About Journal
Arthritis & Rheumatology, an official journal of the American College of Rheumatology, is a peer-reviewed publication for scientists and clinicians interested in the natural history, pathophysiology, treatment, and outcome of the rheumatic diseases. Arthritis & Rheumatology publishes the highest quality basic and clinical research related to the rheumatic diseases, encompassing a wide range of areas of investigative activity. In addition, the journal publishes review articles, editorials, and other educational material intended for both researchers and clinicians. Serving the worldwide community of rheumatology investigators and clinicians, Arthritis & Rheumatology is known internationally as a top rheumatology research journal.
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