Contrary to generally accepted belief, a recent review and analysis of published studies did not reveal a consistent association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen and exacerbation of Crohn’s disease and ulcerative colitis.
Contrary to generally accepted belief, a recent review and analysis of published studies did not reveal a consistent association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen and exacerbation of Crohn’s disease and ulcerative colitis. Nevertheless, when the analysis was limited to studies with a low risk of bias, three was a link between NSAIDs use and exacerbation of Crohn’s disease but not ulcerative colitis.
The Alimentary Pharmacology & Therapeutics analysis included 18 studies published between 1983 and 2016.
“We were surprised to see that there is little data in the literature to support our common recommendation to patients with inflammatory bowel disease to avoid all NSAIDs,” said senior author Dr. Hamed Khalili, of Massachusetts General Hospital.
Additional Information
Link to Study: http://onlinelibrary.wiley.com/doi/10.1111/apt.14606
About Journal
Alimentary Pharmacology & Therapeutics is an international journal of gastroenterology and hepatology.
The journal accepts systematic reviews, meta-analyses, randomised controlled trials and original papers concerned with Gastroenterology and Hepatology.
AP&T is particularly interested in therapies and diagnostics, including all aspects of translation from bench to bedside: identification of novel therapeutic targets, epidemiology, clinical trials, drug safety and meta-analyses.
Josh Glickman
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