Researchers have discovered a new marker of arthritis in mice that can be used non-invasively to both identify joints with established arthritis and to predict subsequent joint swelling.
Researchers have discovered a new marker of arthritis in mice that can be used non-invasively to both identify joints with established arthritis and to predict subsequent joint swelling. The finding is published in Arthritis & Rheumatology.
The investigators note that imaging tests with the marker—called Ratiometric thrombin-Activatable Cell Penetrating Peptide—might help clinicians monitor the development and progression of arthritis and other inflammatory diseases.
“This new imaging tool should allow researchers to localize very early events in arthritis to enable translational advances,” said senior author Dr. Maripat Corr, of the University of California San Diego.
Image: topically applied Ratiometric thrombin-Activatable Cell Penetrating Peptide to a cryosection from a paw of a mouse injected with K/BxN serum demonstrating areas of cleavage in the warmer colors (red/orange).
Additional Information
Link to Study: http://onlinelibrary.wiley.com/doi/10.1002/art.40316/full
About Journal Arthritis & Rheumatology, an official journal of the American College of Rheumatology, is a peer-reviewed publication for scientists and clinicians interested in the natural history, pathophysiology, treatment, and outcome of the rheumatic diseases. Arthritis & Rheumatology publishes the highest quality basic and clinical research related to the rheumatic diseases, encompassing a wide range of areas of investigative activity. In addition, the journal publishes review articles, editorials, and other educational material intended for both researchers and clinicians. Serving the worldwide community of rheumatology investigators and clinicians, Arthritis & Rheumatology is known internationally as a top rheumatology research journal.
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