A new review discusses important consideration when caring for children who have received liver transplants.
A new review discusses important consideration when caring for children who have received liver transplants.
Young patients process immunosuppressive agents differently than older patients, which can have effects on drug absorption, distribution, metabolism, and excretion. Children will also be exposed to immunosuppressive drugs longer than adults, which can impact their growth and their long-term risk of infection and cancer.
“Caring for children after liver transplantation is extremely rewarding thanks to their excellent outcomes,” said Dr. Tamir Miloh, lead author of the Liver Transplantation review. “Tailoring the immunosuppressant regimen in pediatrics is complex, however, due to physiologic differences in pharmacokinetics, impact on growth and development, infection risk, carcinogenesis, and likelihood of non-adherence on one hand and tolerance on the other. Pre-transplant and continuous post-transplant caregiver and patient education is crucial for optimal outcomes.”
Additional Information:
Link to study: http://onlinelibrary.wiley.com/doi/10.1002/lt.24677/abstract
About Journal
Liver Transplantation is published by Wiley on behalf of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Since the first application of liver transplantation in a clinical situation was reported more than twenty years ago, there has been a great deal of growth in this field and more is anticipated. As an official publication of the AASLD and the ILTS, Liver Transplantation delivers current, peer-reviewed articles on surgical techniques, clinical investigations and drug research — the information necessary to keep abreast of this evolving specialty. For more information, please visit http://wileyonlinelibrary.com/journal/lt.
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