Gastric bypass surgery is one of the most successful treatments for obesity and related disorders; however, some patients may not want to undergo surgery.
Gastric bypass surgery is one of the most successful treatments for obesity and related disorders; however, some patients may not want to undergo surgery. In an attempt to reduce nutrient absorption and replicate the effects of gastric bypass surgery, researchers screened for inhibitors of an amino acid transporter, called B0AT1, and discovered a number of agents—including benztropine, a drug that is already in clinical use—as promising candidates.
“These compounds are just a start and need to be developed further, but they could potentially replace surgical procedures and be used together with other drugs to treat type 2 diabetes,” said Dr. Stefan Bröer, senior author of the British Journal of Pharmacology study.
Additional Information
Link to study: http://onlinelibrary.wiley.com/doi/10.1111/bph.13711/abstract
About Journal
The British Journal of Pharmacology is a broad-based journal giving leading international coverage of all aspects of experimental pharmacology. It publishes high quality original research and authoritative reviews. Each year a range of themed issues are published and a must-read supplement, the Concise Guide to Pharmacology is published biennially.
The journal is now published in an online-only format. Issues are published fortnightly but are no longer printed; however, authors are still able to order offprints of their own articles through Author Services.
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