In a study published in the Journal of Bone and Mineral Research, blood tests that detect fragments of a protein secreted by bone cells helped to predict fracture risk in postmenopausal women, independently of bone mineral density, bone turnover markers, and other measures of bone health.
In a study published in the Journal of Bone and Mineral Research, blood tests that detect fragments of a protein secreted by bone cells helped to predict fracture risk in postmenopausal women, independently of bone mineral density, bone turnover markers, and other measures of bone health.
In the study of 695 women, high levels of the fragments were seen in women who later developed fractures compared with those who did not.
The fragments come from a protein named periostin, which is broken down by an enzyme in bone called cathepsin K.
“The periostin fragments’ strong association with incident fractures is largely independent of other bone measures, arguing that they may reflect additional bone properties related to bone quality and strength,” said Dr. Nicolas Bonnet, lead author of the study.
Additional Information
Link to Study: http://onlinelibrary.wiley.com/doi/10.1002/jbmr.3203/full
About Journal
The JBMR publishes highly competitive original manuscripts, reviews, and special articles in basic and clinical science relevant to bone, muscle and mineral metabolism. Manuscripts are published on the biology and physiology of bone and muscle, relevant systems biology topics (e.g. osteoimmunology), and the pathophysiology and treatment of sarcopenia and disorders of bone and mineral metabolism.
Canon Carson
US + 1 201-748-5838 x25838
sciencenewsroom@wiley.com