Non-infected babies born to HIV positive mothers should be vaccinated
early against measles, to avoid them acquiring the virus or passing it
on to others.
A study published in the November issue of Acta Paediatrica found
that even if babies are born without HIV, their maternally derived
protection against measles may be impaired by their mother’s positive
HIV status.
“The eradication of measles is high on the agendas of the World Health
Organization and other international agencies and it is important to
define and target any new group of susceptible infants” says Dr Lars
Smedman from the Department of Paediatrics at Karolinska University
Hospital, Stockholm, Sweden.
According to the World Health Organization, measles is one of the
leading causes of death among young children. Complications of this
highly contagious, serious disease can include bacterial pneumonia,
blindness, destructive ear infections, severe diarrhoea and related
dehydration.
In 2010 there were 139,300 deaths globally, which equates to 380 a day
or 15 an hour. However, in 1980, before widespread immunisation, measles
caused an estimated 2.6 million deaths a year. Immunisations have risen
by 72% since 2000 and in 2010 about 85 per cent of the World’s children
received one dose of the measles vaccine by their first birthday.
Dr Smedman and colleagues compared blood serum samples from ten babies
aged one to four months who were born to HIV mothers, but had not
acquired the infection, to ten healthy babies born to mothers without
HIV.
The mothers ranged from 26 to 35 years of age, were all immigrants and
originated from Ethiopia, the Ivory Coast, Uganda, Kenya and Thailand.
Their viral loads ranged from less than 20 to 8,870 and their CD4 cell
counts from 237 to 754.
Nine gave birth by planned or emergency caesarean, with only one vaginal
birth, and the gestational age of the babies ranged from 32 to 41 weeks.
“We used a new cell ELISA technique to demonstrate how the serum samples
drawn from the infants would inactivate the measles virus” explains Dr
Smedman.
“This found statistically significant differences between the maternal
antibodies received by the two sets of babies and showed that the
non-infected babies born to HIV positive mothers had weaker protection.
This was because the antibodies normally produced by the mother to help
protect her baby from measles had lost their sharp edge due to her HIV
positive status.
“The results suggest that babies born to HIV mothers would not be able
to neutralise the measles virus as effectively and would loose
protection sooner than babies born to healthy mothers. These babies
would therefore be much more likely to succumb to measles and, or, pass
the virus on to other children, making their early immunisation vital.”
The paper is free online at: http://onlinelibrary.wiley.com/doi/10.1111/j.1651-2227.2012.02793.x/abstract
